In Nadodimannan, Padmanabhan (Dileep) plays a village youth who does not have a particular inclination towards any political party and joins any protest being held. He earns a living by participating in demonstrations for various political parties. He then reaches the city where he is strung to the upper levels of society and gets elected as the Mayor. His conflicts and attempts to cleanse the city form the rest of the story. Ananya plays the character of Meera, who lives in difficult surroundings, but is bold. Archana Kavi plays Aathira, a member of a former royal family, Mythili stars as Rima, a broadcast journalist Padmanabhan befriends during his activist days, who helps him bring to light certain crucial issues before the public.